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KMID : 0613820170270111357
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Journal of Life Science
2017 Volume.27 No. 11 p.1357 ~ p.1368
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Anti-obesity and Anti-inflammation Effects of Cheonggukjang in C57Bl/6 mice with High Fat Diet Induced Obesity
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Kim Ji-Young
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Abstract
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The purpose of this study was to investigate the anti-obesity and anti-inflammation effect of the cheonggukjang (a soybean paste fermented for only a few days) in diet induced obesity mice. Weight gain was significantly decreased in the mice fed cheonggukjang compared High Fat Diets (HFD). The HFD plus cheonggukjang (CGJ) were also effective in improving the lipid metabolism. The levels of plasma triglyceride, cholesterol, ALT, AST, leptin, glucose, and insulin were significantly lower in CGJ than HFD group (p<0.05). The adiponectin level of CGJ group was significantly increased compared to the HFD group (p<0.05). In the CGJ group, the mRNA expression of adipogenic genes in the liver and adipose tissues, which are transcription factors crucial for adipogenesis, were significantly suppressed (p<0.05). The number of CD11b+F4/80+ T cells, Gr-1intCD11bhigh cells, and Gr-1intCD11bhigh cells were significantly higher in HFD group than CGJ group (p<0.05). The size of adipocyte was significantly reduced in CGJ group compared to HFD group. In addition, the contents of liver lipid droplets were significantly downregulated in the CGJ mice than HFD mice (p<0.05). Collectively, these data suggest the novel function of cheonggukjang in modulating adipogenesis through an immune function-alteration involving downregulation of adipogenic transcription factors and macrophage activation.
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KEYWORD
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Cheonggukjang, DIO mice, inflammation, obesity, soybean
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